Table 4. Summary and comparison of phenotypes observed to previous published findings.
CC = corpus callosum, AC = anterior commissure, amyg = amygdala. References: Eagleson [15], Shen [16], Miyoshi [14].
| Domain | Study | Publication | Finding | FOXG1 allele | Strain | Age |
|---|---|---|---|---|---|---|
| Brain structure | Brain size | Eagleson | Decreased cerebral hemisphere length/width | Foxg1-Cre | C57BL/6J | P4 and P60 |
| Brain weight | This study | Decreased overall brain weight | FoxG1-tm4144Tac | C57BL/6J | adult | |
| Brain MRI | Eagleson | Decreased volume neocortex, striatum, hippocampus, thalamus | Foxg1-Cre | C57BL/6J | adult | |
| Brain MRI | This study | Decreased overall whole brain volume (WBV). Decreased WBV corrected volume CC, amyg, increased temp. limb AC, pons | FoxG1-tm4144Tac | C57BL/6J | 48 wks | |
| Locomotor activity | Open field | Shen | Increased distrance travelled, decreased habituation | FoxG1-tTA | C57BL/6 (no substrain) |
8-10wks |
| Open field | Miyoshi | no difference from WT | FoxG1-lacZ | not specified | 5 wks | |
| Open field | This study | Decreased distrance travelled, vertical activity, and center of field distance/total distance |
FoxG1-tm4144Tac | C57BL/6J | 8-11wks | |
| Gait | This study | Changes in a number of parameters | FoxG1-tm4144Tac | C57BL/6J | 9–12 wks | |
| Rotarod | This study | no diffference from WT | FoxG1-tm4144Tac | C57BL/6J | 15 wks | |
| Anxiety | Elevated Plus Maze | Miyoshi | Increased open arm time (decreased anxiety) |
FoxG1-lacZ | not specified | 5 wks |
| Elevated Zero Maze | This study | Increased open area distance (decreased anxiety) |
FoxG1-tm4144Tac | C57BL/6J | 17-22wks | |
| Learning and Memory | Conditioned Fear | Shen | Decresed freezing in context | FoxG1-tTA | C57BL/6 (no substrain) |
12–14 wks |
| Conditioned Fear | This study | Decreased freezing in context and cue | FoxG1-tm4144Tac | C57BL/6J | 13–14 wks | |
| 8-arm radial maze | Miyoshi | Impaired working memory | FoxG1-lacZ | not specified | 6 wks | |
| Social | 3-Chamber Test | Miyoshi | Deccreased Sociability, Decreased Novelty | FoxG1-lacZ | not specified | 6 wks |
| 3-Chamber Test | This study | Increased Sociability, Decreased Novelty | FoxG1-tm4144Tac | C57BL/6J | 9 wks | |
| Nest building | This study | Decreased next building score | FoxG1-tm4144Tac | C57BL/6J | 14–15 wks | |
| Compulsive Behavior | Marble burying | This study | Decreased percentage marbles buried | FoxG1-tm4144Tac | C57BL/6J | 13 wks |
| Aggression | Tube Test | This study | Increased average number of wins | FoxG1-tm4144Tac | C57BL/6J | 11–12 wks |