Table 2. Associations between seropositivity for 16 IgG antibody measures and dementia risk.

Virus type	Seropositivity	Dementia		Dementia				OR*	95% C.I.		P-value#
		Controls		Cases		Total
		n	%	n	%	n	%
Herpes Simplex virus-1	Negative	2,824	30.22	14	16.47	2,838	30.09	Ref
	Positive	6,522	69.78	71	83.53	6,593	69.91	2.14	1.21	3.81	0.010
Herpes Simplex virus-2	Negative	7,832	83.8	74	87.06	7,906	83.83
	Positive	1,514	16.2	11	12.94	1,525	16.17	0.78	0.41	1.47	0.440
Varicella Zoster virus	Negative	713	7.63	2	2.35	715	7.58
	Positive	8,633	92.37	83	97.65	8,716	92.42	3.38	0.83	13.78	0.089
Epstein-Barr virus	Negative	493	5.27	5	5.88	498	5.28
	Positive	8,853	94.73	80	94.12	8,933	94.72	0.9	0.36	2.24	0.823
Human Cytomegalovirus	Negative	3,901	41.74	37	43.53	3,938	41.76
	Positive	5,445	58.26	48	56.47	5,493	58.24	0.89	0.57	1.37	0.587
Human Herpesvirus-6	Negative	866	9.27	3	3.53	869	9.21
	Positive	8,480	90.73	82	96.47	8,562	90.79	2.79	0.88	8.85	0.082
Human Herpesvirus-7	Negative	501	5.36	2	2.35	503	5.33
	Positive	8,845	94.64	83	97.65	8,928	94.67	2.4	0.59	9.8	0.222
Kaposi Sarcoma-Associated Herpesvirus	Negative	8,594	91.95	77	90.59	8,671	91.94
	Positive	752	8.05	8	9.41	760	8.06	1.19	0.57	2.48	0.634
Hepatitis B virus	Negative	9,114	97.52	84	98.82	9,198	97.53
	Positive	232	2.48	1	1.18	233	2.47	0.48	0.07	3.48	0.470
Human T-Lymphotropic Virus 1	Negative	9,200	98.44	84	98.82	9,284	98.44
	Positive	146	1.56	1	1.18	147	1.56	0.72	0.1	5.21	0.745
Human Polyomavirus BKV	Negative	438	4.69	4	4.71	442	4.69
	Positive	8,908	95.31	81	95.29	8,989	95.31	1.04	0.38	2.87	0.933
Human Polyomavirus JCV	Negative	3,976	42.54	34	40	4,010	42.52
	Positive	5,370	57.46	51	60	5,421	57.48	1.12	0.73	1.74	0.599
Merkel Cell Polyomavirus	Negative	3,131	33.5	28	32.94	3,159	33.5
	Positive	6,215	66.5	57	67.06	6,272	66.5	1.04	0.66	1.64	0.870
Human Papillomavirus type-16 (Definition I)	Negative	8,934	95.59	79	92.94	9,013	95.57
	Positive	412	4.41	6	7.06	418	4.43	1.8	0.78	4.19	0.169
Human Papillomavirus type-16 (Definition II)	Negative	8,917	95.41	81	95.29	8,998	95.41
	Positive	429	4.59	4	4.71	433	4.59	1.03	0.37	2.82	0.958
Human Papillomavirus type-18	Negative	9,097	97.34	83	97.65	9,180	97.34
	Positive	249	2.66	2	2.35	251	2.66	0.93	0.23	3.79	0.914

*Adjusted for age as categorical variable (≤65 VS >65).

N.B.: (Age was also fitted as a continuous variable but this did not affect the results).

#P-value adjusted for multiple testing.