Table 1. Demographic and clinical characteristics of patients in the West Africa derivation cohort.
| Characteristic | Survived, n = 345 | Died, n = 234 | OR (95% CI)a | p-valueb |
|---|---|---|---|---|
| Demographics | ||||
| Age (years), median (IQR) | 11 (7, 14) | 6 (3, 13) | 0.55 (0.46–0.65) | <0.001 |
| Male sex, n (%) | 159 (46) | 112 (48) | 1.07 (0.77–1.5) | 0.67 |
| Symptoms c | ||||
| Asthenia | 297 (88) | 171 (74) | 0.39 (0.25–0.6) | <0.001 |
| Headache | 203 (60) | 93 (42) | 0.48 (0.34–0.68) | <0.001 |
| Abdominal pain | 165 (50) | 78 (36) | 0.57 (0.4–0.81) | 0.002 |
| Bleeding | 43 (14) | 45 (22) | 1.68 (1.06–2.67) | 0.027 |
| Joint pain | 113 (38) | 48 (29) | 0.68 (0.45–1.01) | 0.060 |
| Bone or muscle pain | 121 (37) | 61 (29) | 0.71 (0.48–1.02) | 0.067 |
| Respiratory distress | 26 (7.9) | 27 (13) | 1.69 (0.95–2.99) | 0.071 |
| Vomiting | 206 (61) | 121 (54) | 0.76 (0.54–1.07) | 0.12 |
| Nausea | 172 (60) | 104 (54) | 0.78 (0.54–1.13) | 0.19 |
| Conjunctivitis | 47 (18) | 20 (15) | 0.8 (0.45–1.4) | 0.45 |
| Diarrhea | 187 (56) | 125 (59) | 1.13 (0.8–1.61) | 0.48 |
| Hiccups | 24 (7.3) | 12 (5.7) | 0.77 (0.37–1.55) | 0.48 |
| Fever | 298 (88) | 199 (87) | 0.88 (0.54–1.46) | 0.63 |
| Anorexia | 225 (74) | 128 (75) | 1.10 (0.72–1.70) | 0.67 |
| Swallowing problems | 60 (18) | 40 (19) | 1.01 (0.64–1.57) | 0.97 |
| Ct value, median (IQR) | 26.8 (23.6, 30.8) | 21.7 (18.9, 26.5) | 0.35 (0.23–0.51) | <0.001 |
aOR is for each 5-year increase in age
bBold values denote statistical significance
cn (%)
Abbreviations: IQR: interquartile range; Ct: cycle threshold; OR: odds ratio; CI: confidence intervals