Figure 4.

Sex-based assessment of iNOS and CD80 (M1) and, Arg1 and FIZZ1 (M2) expression in the lungs of GBS-infected mice (24 h pi). C57BL/6 male (black) and female (white) mice were infected intranasally with ± 10⁸ CFUs of GBS (n = 15/group). Relative mRNA transcripts of iNOS, CD80, Arg1 and FIZZ1 were evaluated 24 h pi in the lungs using real-time RT-PCR. The values were normalized with two internal controls, RPL-19 and β-actin. Relative expression results were compared to those obtained for uninfected male (n = 10) and female (n = 10) control mice. *p < 0.05, **p < 0.01 (Mann–Whitney U test). Data are representative of three independent experiments.