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Cumulative incidence curves for the study end points over follow-up by the presence or absence of a protein-altering variant across both cohorts. Major arrhythmia composite includes hemodynamically unstable ventricular tachycardia, aborted sudden cardiac death, implantable cardioverter defibrillator, or heart block (second or third degree). Major heart failure composite includes heart transplantation, left ventricular assist device implantation, or heart failure hospitalization.
