A. Schematic depiction of a detailed model of a linear strand of myocytes. B. Particular multiscale representation of the tissue domain shown in panel A. Here, dark lines indicate the “unresolved” region, where the macroscale equations are employed, and the thin broken lines indicate the “resolved” region, where the microscale equations are employed. C. Possible discretization of the multiscale representation shown in panel B. In the discretization depicted in this panel, the coarse macroscopic grid spacing Δxmacro is on the order of two cell lengths, whereas the fine microscopic grid spacing Δxmicro uses five grid points per cardiac cell. Figure from Hand and Griffith [29].