TABLE 1.
Etiology of Proven HAI in VLBW Infants (n = 162)
| Organism | Number (%) | Median Age at Onset (d, IQR) | Crude Mortality by Causative Pathogen (%) | |||
|---|---|---|---|---|---|---|
| Gram-negative organisms | 84 | (51.9) | 7 | (5–10) | 33 | (39.3) |
| A. baumannii | 24 | (14.8) | 5 | (4–6) | 11 | (45.8) |
| Klebsiella spp. | 23 | (14.2) | 8 | (6–10) | 8 | (34.8) |
| S. marcescens | 20 | (12.3) | 7 | (5–10) | 7 | (35.0) |
| E. coli | 7 | (4.3) | 16 | (9–26) | 2 | (28.6) |
| Other* | 10 | (6.2) | 7 | (5–15) | 5 | (50.0) |
| Gram-positive organisms | 56 | (34.6) | 11 | (7–18) | 13 | (23.2) |
| S. aureus | 30 | (18.5) | 10 | (7–16) | 8 | (26.7) |
| Enterococcus spp. | 10 | (6.1) | 11 | (7–13) | 4 | (40.0) |
| CoNS | 9 | (5.6) | 15 | (11–33) | 0 | (0.0) |
| S. agalactiae | 7 | (4.3) | 28 | (13–32) | 1 | (14.3) |
| Polymicrobial growth | 22 | (13.6) | 10 | (5–18) | 9 | (40.9) |
| Gram-negative only | 6 | (27.3%) | 4 | (4–8) | 6 | (100.0) |
| Gram-positive only | 7 | (31.8%) | 11 | (5–32) | 2 | (28.6) |
| Mixed growth | 9 | (40.9%) | 12 | (10–21) | 1 | (11.1) |
| Total | 162 | (100.0) | 9 | (6–13) | 55 | (34.0) |
*
Other: E. cloacae (n = 3, P. aeruginosa (n = 2), P. mirabilis (n = 2), unspecified other (n = 3).
CoNS indicates coagulase-negative staphylococci; HAI, healthcare-associated infection; IQR, interquartile range; VLBW, very low birth weight.