Table 2.
Measured Acetaminophen Concentrations by Arm
| Treatment Arm | ||
|---|---|---|
| Acetaminophen (ng/mL) |
Control (ng/mL) |
|
| Time, hours | ||
| 0 | 1601 (124–6660) | 5122 (379–11051) |
| 6 | 4235 (2706–5788) | 2399 (693–5401) |
| 12 | 4824 (3263–6807) | 750 (188–3036) |
| 18 | 4434 (2996–6507) | 436 (118–1107) |
| 24 | 4461 (3515–6362) | 107 (0–430) |
| 30 | 4341 (3150–6698) | 40 (0–141) |
| 36 | 4233 (3002–5980) | 0 (0–55) |
| 42 | 3967 (2983–5868) | 0 (0–110) |
| 48 | 3687 (2674–5469) | 0 (0–0) |
| 54 | 3363 (2419–4797) | 0 (0–0) |
| 60 | 3334 (2452–4820) | 0 (0–0) |
| 66 | 3129 (1987–4632) | 0 (0–0) |
| 72 | 2959 (2017–4143) | 0 (0–0) |
Values are median (interquartile range). Acetaminophen levels were higher in the acetaminophen arm compared with the control arm at all time points (P < .001 for all comparisons), except for enrollment when concentrations were higher in the control arm (P = .014).