Table 3.
Group | Total N | % Change in Creatinine a (Acetaminophen) | n (Acetaminophen) | % Change in Creatinine a (Control) | n (Control) | Analysis of Covariance Coefficient b | P Value |
---|---|---|---|---|---|---|---|
Entire cohort | 365 | –14.9 (18.1) | 181 | –14.6 (16.0) | 184 | –0.0056 (–0.050 to 0.039) | 0.81 |
Maximum CFHb ≥77 600c ng/mL | 182 | –17.3 (19.3) | 100 | –14.8 (15.2) | 82 | –0.040 (–0.11 to 0.028) | 0.25 |
Maximum CFHb <77 600 ng/mL | 183 | –15.3 (16.2) | 82 | –14.6 (16.7) | 101 | –0.038 (–0.021 to 0.097) | 0.20 |
Severe malaria subgroup | |||||||
Severe malaria | 33 | –31.0 (26.5) | 16 | –20.4 (21.5) | 17 | –0.20 (–0.45 to 0.53) | 0.12 |
Maximum CFHb ≥77 600 ng/mL | 22 | –35.8 (26.7) | 13 | –19.0 (16.6) | 9 | –0.30 (–0.63 to 0.03) | 0.07 |
Maximum CFHb <77 600 ng/mL | 3 | –10.2 (13.8) | 8 | –21.9 (27.1) | 3 | –0.44 (–0.21 to 1.09) | 0.15 |
Uncomplicated malaria | 332 | –13.3 (16.4) | 165 | –14.1 (15.2) | 167 | –0.006 (–0.037 to 0.025) | 0.69 |
Maximum CFHb ≥77 600 ng/mL | 160 | –14.5 (16.5) | 87 | –14.3 (15.1) | 73 | –0.021 (–0.061 to 0.019) | 0.31 |
Maximum CFHb <77 600 ng/mL | 172 | –12.0 (16.3) | 79 | –14.0 (15.5) | 93 | 0.015 (–0.032 to 0.061) | 0.54 |
AKI subgroup | |||||||
AKI | 109 | –28.5 (21.2) | 53 | –27.4 (16) | 56 | –0.057 (–0.16 to 0.043) | 0.26 |
Maximum CFHb ≥77 600 ng/mL | 56 | –34.5 (20.7) | 31 | –25.9 (15.8) | 25 | –0.15 (–0.30 to –0.0065) | 0.041 |
Maximum CFHb <77 600 ng/mL | 53 | –20.0 (19.2) | 22 | –28.5 (–16.6) | 31 | 0.080 (–0.55 to 0.22) | 0.24 |
No AKI | 256 | –9.3 (13.2) | 128 | –9.1 (12.3) | 128 | –0.0085 (–0.040 to 0.23) | 0.60 |
Maximum CFHb ≥77 600 ng/mL | 126 | –9.6 (12.6) | 69 | –9.9 (12.1) | 57 | –0.0089 (–0.051 to 0.034) | 0.68 |
Maximum CFHb <77 600 ng/mL | 129 | –9.0 (14.0) | 59 | –8.5 (12.6) | 70 | –0.0031 (–0.051 to 0.045) | 0.90 |
Abbreviations: AKI, acute kidney injury; CFHb, cell-free hemoglobin.
Mean percent change in creatinine from 0 to 72 hours (SD).
Analysis of covariance in change in log-transformed creatinine from 0 to 72 hours using baseline creatinine as a covariate. Coefficient (95% confidence interval).
Median maximum CFHb.