Table 4.

Parasite Clearance Metrics

Variable	Treatment Arm
	Acetaminophen (n = 105)	Control (n = 110)	P Value
PCT, median (IQR), hours	26.0 (21.3 to 30.9)	25.1 (20.8 to 29.7)	.19
Clearance rate constant, median (IQR), hours	0.27 (0.23 to 0.33)	0.30 (0.25 to 0.35)	.025
Slope half-life, median (IQR), hours	2.61 (2.12 to 3.0)	2.30 (1.97 to 2.73)	.025
PC50, median (IQR), hours	5.7 (3.7 to 9.1)	4.8 (3.6 to 7.4)	.15
PC90, median (IQR), hours	11.8 (9.4 to 15.2)	11.4 (9.0 to 13.7)	.044
PC95, median (IQR), hours	14.6 (11.7 to 18.0)	13.9 (10.9 to 16.5)	.027
PC99, median (IQR), hours	20.5 (17.4 to 24.4)	19.8 (15.5 to 22.3)	.028

PCT: time in hours until first of 2 consecutive negative blood films. PC50: estimated time in hours for parasitemia to reduce by 50% of initial value. PC90: estimated time in hours for parasitemia to reduce by 90% of initial value. PC95: estimated time in hours for parasitemia to reduce by 95% of initial value. PC99: estimated time in hours for parasitemia to reduce by 99% of initial value.

Abbreviations: IQR, interquartile range; PCT, parasite clearance time.