Figure 2.

Human immunodeficiency virus (HIV) RNA changes over time. A, Cell-associated unspliced HIV RNA measured in total CD4 cells at baseline (average of 2 measurements), at day 28 after either 4 weeks of tamoxifen (arm A) or observation (arm B), and 5 hours after the second dose of vorinostat (day 38). B, Spliced HIV RNA as measured with the EDITS assay in resting memory CD4 cells at the same time points. Symbols indicate geometric mean, bars Q1 (first quartile [25th percentile]), Q3 (third quartile [75th percentile]). Open symbols in (A) indicate geometric mean when using participant-specific lower levels of quantification. There was no significant difference between the study arms in the induction of HIV RNA by either assay. Abbreviations: caRNA, cell-associated RNA; TAMOX, tamoxifen; VOR, vorinostat.