TABLE 2.

Potential Participant Barriers and Solutions

Potential Barrier	Mitigation Plan
Lack of early engagement with participants, as many potential participants won’t have recurring symptoms after discharge from hospital	1) Encourage clinical research coordinator to reach out to participants. 2) Have a dedicated staff member whose main role is outreach. 3) Automated outreach via MyChart (or similar methods) per local IRB guidelines.
Long-term participation in the study is too burdensome	1) Study procedures that can be done remotely have been identified and will be discussed with participants. 2) Identify barriers to retention early and modify study based on the participant perceptions. 3) Allow flexibility in timing of study visits. 4) Provide ride services if needed or pay for parking and travel-related costs.
Competing studies limiting available participants	1) All sites have agreed to prioritize the DREAM study. 2) Enrollment into DREAM study will not preclude participation in other studies. 3) New studies enrolling an overlapping population will be reviewed on a case-by-cases basis to ensure participant safety and integrity.