TABLE 5.

Potential off-target sites for IFNAR1 and IFNAR2 targeting vectors.

On/off target		Locus	Chromosome	Sequence	Mismatch	Score
On target		IFNAR1	chr1	AGA​AAT​TGT​CAT​CAA​TGA​TG TGG	-	-
Off target	OFT1	5,008	chr8	TGA​AGT​TGT​CAT​CAA​TGA​TG GAG	2	6.0
	OFT2	5,852	chr8	TGA​AGT​TGT​CAT​CAA​TGA​TG GAG	2	6.0
	OFT3	91941448	chr9	TGA​AAT​TAT​GAT​CAA​TGA​TG GGG	3	2.7
	OFT4	31647797	chr23	ACA​TAT​TGT​CAT​CAA​TGA​TA CAG	3	1.9
	OFT5	65232401	chr9	TCA​ACT​TGT​AAT​CAA​TGA​TG CAG	4	1.5
	OFT6	30230581	chr1	AGA​ATT​TGA​AAT​CAA​TGA​TG GGG	3	1.5
	OFT7	51384676	chr3	ACA​AAT​TGT​AAG​CAA​TGA​TG TGG	3	1.4
	OFT8	ENSOARG00000017529	chr1	AGA​ACT​TGG​CAT​GAA​TGA​TG AAG	3	0.7
	OFT9	ENSOARG00000011021	chr21	TGA​AAG​TGT​CAT​CAG​TGA​TG GAG	3	0.6
	OFT10	ENSOARG00000018971	chr15	AAA​TAT​TGG​CCT​CAA​TGA​TG TGG	4	0.5
On target		IFNAR2	chr6	ACC​ACT​GAA​TTT​GTA​TCC​CA GGG	-	-
Off target	OFT11	144799426	chr1	AAC​ACT​GGT​TTT​GTA​TCC​CA GGG	3	1.7
	OFT12	464	chr5	GCA​CCT​GTA​TTT​GTA​TCC​CA GGG	4	1.5
	OFT13	82466814	chr5	AAT​GAT​GAA​TTT​GTA​TCC​CA AAG	4	1.3
	OFT14	39610637	chr12	CTC​CCT​GAA​TTT​GTA​TCC​CT GGG	4	0.9
	OFT15	108244924	chrX	ATC​CCT​GGA​TGT​GTA​TCC​CA GGG	4	0.9
	OFT16	57537802	chr4	ACA​TAT​GAT​TTT​GTA​TCC​CA GAG	4	0.9
	OFT17	54969806	chr5	GCC​TCT​GAA​GAT​GTA​TCC​CA AAG	4	0.9
	OFT18	20531845	chr6	ACT​ATT​GAA​AGT​GTA​TCC​CA TAG	4	0.8
	OFT19	99052667	chr5	AGC​TCT​GTA​TTT​ATA​TCC​CA GGG	4	0.7
	OFT20	44679365	chr10	TCC​TTT​GAA​TTT​ATA​TCC​CA AGG	4	0.7