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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Genet. 2022 Oct;54(10):1451–1452. doi: 10.1038/s41588-022-01195-9

Fig. 1 |. Mutations observed in sleep apnea probands show impaired TASK-1 channel function, as evaluated in X. oocytes.

Fig. 1 |

Mutations in KCNK3 results in reduced open probability (PO) and deficient activation through GPCRs in TASK-1 channels, disrupting the proper functioning of the TASK-1 channel X-gate. BAY1000493 denotes a potent TASK-1 inhibitor compound. M1–M4, transmembrane helix units; Gαq, protein G alpha q subunit.