Table 1:
Demographic and Disease Characteristics of elderly patients with HPV+ and HPV− OPSCC
| Variable | HPV+ (n=62) | HPV− (n=26) | All Patients (n =88) | p-valuea |
|---|---|---|---|---|
| Age, years | 0.56 | |||
| Median (IQR) | 74 (71–79) | 73 (71–77) | 73 (71–78) | |
| Gender, n (%) | 0.36 | |||
| Male | 47 (76) | 22 (85) | 69 (78) | |
| Female | 15 (24) | 4 (15) | 19 (22) | |
| Race/Ethnicity, n (%) | 0.007 | |||
| White | 47 (76) | 11 (42) | 58 (66) | |
| Black | 6 (10) | 7 (27) | 13 (15) | |
| Other | 4 (6) | 1 (4) | 5 (6) | |
| Hispanic | 5 (8) | 7 (27) | 12 (14) | |
| Alcohol, n (%) | 0.007 | |||
| Never/Moderate drinker | 54 (87) | 16 (62) | 70 (80) | |
| Former Heavy drinker | 3 (5) | 7 (27) | 10 (11) | |
| Current Heavy drinker | 5 (8) | 3 (12) | 8 (9) | |
| Smoking, n (%) | 0.88 | |||
| Never | 19 (31) | 7 (27) | 26 (30) | |
| Former | 38 (61) | 16 (62) | 54 (61) | |
| Current | 5 (8) | 3 (12) | 8 (9) | |
| Smoking Pack Years, n (%) | 0.99 | |||
| Never | 19 (31) | 7 (27) | 26 (30) | |
| ≤10 pack years | 11 (18) | 5 (19) | 16 (18) | |
| 10–≤20 pack years | 6 (10) | 3 (12) | 9 (10) | |
| >20 | 26 (42) | 11 (42) | 37 (42) | |
| ECOG, n (%) | 0.009 | |||
| 0 | 31 (50) | 6 (23) | 37 (42) | |
| 1 | 23 (37) | 12 (46) | 35 (40) | |
| 2 | 8 (13) | 5 (19) | 14 (16) | |
| 3 | 0 (0) | 3 (12) | 3 (3) | |
| Charleston Comorbidity Index | 0.66 | |||
| Median (IQR) | 6(5–7) | 6(5–7) | 6 (5–7) | |
| Stage (AJCC 8th edition), n (%) | <.001 | |||
| I | 23 (37) | 0 (0) | 23 (26) | |
| II | 27 (44) | 4 (15) | 31 (35) | |
| III | 12 (19) | 3 (12) | 15 (17) | |
| IVA | 0 (0) | 10 (38) | 10 (11) | |
| IVB | 0 (0) | 9 (35) | 9 (10) | |
| Primary Site, n (%) | 0.04b | |||
| Base of tongue | 35 (56) | 17 (65) | 52 (59) | |
| Palatine Tonsils | 26 (42) | 6 (23) | 32 (36) | |
| Other | 1 (2) | 3 (12) | 4 (5) | |
| HPV subtype, n (%) | n=42 | <.001 | ||
| 16 | 35 (83) | N/A | 35 | |
| 18 | 2 (5) | 2 | ||
| 33 | 1 (2) | 1 | ||
| 35 | 4 (10) | 4 |
a;
p-values relate to HPV+ versus HPV−
b;
p-value=0.16 when other is not included in statistical analysis