Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 12;610(7931):319–326. doi: 10.1038/s41586-022-05277-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 9 — a. Schematic of experimental preparation for electrically activating rat tissue while performing whole cell recordings from t-hCO neurons. b. Left, current traces from a representative t-hCO neuron following electrical stimulation in white matter with (purple) or without (black) NBQX. Middle, quantification of EPSC amplitude with or without NBQX (paired t-test, *P = 0.0295). Right, percentage of t-hCO neurons that displayed EPSCs in response to electrical stimulation in white matter. c. Left, Current traces from a representative t-hCO neuron following electrical stimulation of t-hCO with (purple) or without (black) NBQX. Middle, quantification of EPSC amplitude with or without NBQX (Wilcoxon test, **P = 0.0022). Right, percentage of t-hCO neurons that displayed EPSCs in response to electrical stimulation of t-hCO. d. Latency to EPSC in t-hCO neurons following electrical stimulation of somatosensory cortex (S1, n = 13 neurons), internal capsule (IC, n = 7 neurons), white matter (WM, n = 8 neurons), or t-hCO (n = 11 neurons). e. Schematic of experimental preparation for optogenetically activating rat thalamic terminals in t-hCO while performing whole cell recordings from t-hCO neurons. f. Top, example recorded t-hCO neuron. Bottom, current traces from a representative t-hCO neuron following optogenetic activation of rat thalamic terminals in t-hCO with (purple) or without (black) NBQX. g, Left, latency to EPSC in t-hCO neurons following optogenetic activation of rat thalamic terminals in t-hCO (n = 7 neurons, 2 animals). Right, percentage of t-hCO neurons that displayed EPSCs in response to optogenetic activation of rat thalamic terminals in t-hCO. Data are presented as mean ± SEM.