Table 3.
Toxicity after CAR T infusion according to CAR T product in the PSM cohorts
| axi-cel | tisa-cel | P | |||
|---|---|---|---|---|---|
| n = 209 | n = 209 | ||||
| CRS of any grade | 180 | (86.1%) | 158 | (75.6%) | 0.006 |
| Grade 1–2 | 169 | (80.9%) | 139 | (66.5%) | <0.001 |
| Grade ≥3 | 11 | (5.3%) | 19 | (9.1%) | 0.130 |
| ICANS of any grade | 102 | (48.8%) | 46 | (22.0%) | <0.001 |
| Grade 1–2 | 73 | (34.9%) | 40 | (19.1%) | <0.001 |
| Grade ≥3 | 29 | (13.9%) | 6 | (2.9%) | <0.001 |
| Cytopenia of any grade at M1 | 135 | (64.6%) | 82 | (39.2%) | <0.001 |
| Grade 1–2 | 64 | (30.6%) | 56 | (26.8%) | 0.387 |
| Grade ≥3 | 71 | (34.0%) | 26 | (12.4%) | <0.001 |
| Neutropenia of any grade at M1 | 124 | (59.3%) | 57 | (27.3%) | <0.001 |
| Grade 1–2 | 71 | (34.0%) | 37 | (17.7%) | <0.001 |
| Grade ≥3 | 53 | (25.4%) | 20 | (9.6%) | <0.001 |
| Anemia of any grade at M1 | 94 | (45.0%) | 58 | (27.8%) | <0.001 |
| Grade 1–2 | 90 | (43.1%) | 58 | (27.8%) | 0.001 |
| Grade ≥3 | 4 | (1.9%) | 0 | (0.0%) | 0.044 |
| Thrombocytopenia of any grade at M1 | 116 | (55.5%) | 62 | (29.7%) | <0.001 |
| Grade 1–2 | 70 | (33.5%) | 43 | (20.6%) | 0.003 |
| Grade ≥3 | 46 | (22.0%) | 19 | (9.1%) | <0.001 |
| Cytopenia of any grade at M3 | 75 | (35.9%) | 29 | (13.9%) | <0.001 |
| Grade 1–2 | 51 | (24.4%) | 21 | (10.0%) | <0.001 |
| Grade ≥3 | 24 | (11.5%) | 8 | (3.8%) | 0.003 |
| Neutropenia of any grade at M3 | 62 | (29.7%) | 22 | (10.5%) | <0.001 |
| Grade 1–2 | 44 | (21.1%) | 16 | (7.7%) | <0.001 |
| Grade ≥3 | 18 | (8.6%) | 6 | (2.9%) | 0.012 |
| Anemia of any grade at M3 | 52 | (24.9%) | 15 | (7.2%) | <0.001 |
| Grade 1–2 | 51 | (24.4%) | 13 | (6.2%) | <0.001 |
| Grade ≥3 | 1 | (0.5%) | 2 | (1.0%) | 0.562 |
| Thrombocytopenia of any grade at M3 | 58 | (27.8%) | 20 | (9.6%) | <0.001 |
| Grade 1–2 | 40 | (19.1%) | 13 | (7.7%) | <0.001 |
| Grade ≥3 | 18 | (8.6%) | 4 | (1.9%) | 0.002 |
Toxicities were graded according to CTCAE version 5.0 for cytopenias and according to the consensus grading from the ASTCT for CRS and ICANS. Only patients who experienced at least grade ≥1 toxicity are reported in the table. M1, 1 month; M3, 3 months.