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. 2022 Sep 12;28(10):2155–2161. doi: 10.1038/s41591-022-01962-5

Extended Data Fig. 7. Immune cell subsets with significant (two-sided p < 0.05) changes in abundance before (baseline) and after (at surgery) neoadjuvant treatment with atezolizumab. No adjustment was made for multiplicity.

Extended Data Fig. 7

A, CD45+ CD62L+ CD27+ CD56/16 CD45RO+ CCR7 CD45RA CD4 CD3+ CD8+ (p = 0.0081); B, CD45+ CD33+ HLA-DR+ CD124 CD14+ CD11b+ CD66b CD16 CD33+ CD15+ (p = 0.0042); C, CD45+ HLA-DR+ CD124 CD14+ CD11b+ CD66b CD16 CD33+ CD15+ (p = 0.0042); D, CD45+ CD94+ NKG2D+ CD3 CD56+ CD117 NKG2A+ CD127 CD161 CD16+ (p = 0.0036); E, CD45+ LIN+ HLA-DR+ CD33+ CD16+ CD11b+ CD15+ (p = 0.0092); F, CD45+ HLA-DR CD69+ CD19 CD56+ CD16 CD134 CD4 CD3+ CD8+ (p = 0.0079); G, CD45+ CD11b+ HLA-DR+ CD124 CD14+ CD11b+ CD66b CD16 CD33+ CD15+ (p = 0.0157); H, CD45+ γ/δ- α/β+ CD19 CD56+ CD16 CD13/14 CD4+ CD3+ CD8 (p = 0.0113); I, CD45+ HLA-DR CD69+ CD3+ KIR3DL1 KIR2DL2 NKG2A CD56+ KIR2DL1 CD16 (p < 0.0001); J, CD45+ CD107a/b- CD159c+ CD3 KIR3DL1 KIR2DL2 NKp80+ CD56+ KIR2DL1 CD16+ (p = 0.0025); K, CD45+ HLA-DR CD69+ CD19 CD56+ CD16 CD134 CD4 CD3+ CD8 (p = 0.0004); L, CD45+ CD16+ CD336 CD3 CD244+ CD335+ NKG2D+ CD56 CD161+ CD337 (p = 0.0002); M, CD45+ γ/δ- α/β+ CD19 CD56+ CD16 CD13/14 CD4 CD3+ CD8 (p = 0.0191); N, CD45+ HLA-DR CD69+ CD3+ KIR3DL1 KIR2DL2 NKG2A+ CD56+ KIR2DL1 CD16 (p = 0.0307); O, CD45+ CD62L CD27+ CD56/16+ CD45RO CCR7 CD45RA+ CD4 CD3+ CD8+ (p = 0.0400); P, CD45+ CD94 NKG2D CD3+ CD56+ CD117 NKG2A CD127+ CD161+ CD16+ (p = 0.0480); Q, CD45+ HLA-DR+ CD69+ CD3 KIR3DL1 KIR2DL2 NKG2A+ CD56 KIR2DL1 CD16+ (p = 0.0014); R, CD45+ LIN HLA-DR CD33 CD16+ CD11b+ CD15+ (p = 0.0030). *Pre-treatment predictor of MPR. LIN included CD19, CD3, and CD56. NKG2A is also known as CD159a, NKG2D as CD314 and KLRK1, KIR2DL1 as CD158a, KIR2DL2 as CD158b, CD335 as NKp46, and CD337 as NKp30. α/β, α/β chains of the T cell receptor; γ/δ, γ/δ chains of the T cell receptor; CCR7, C-C motif chemokine receptor 7; CD, cluster of differentiation; HLA, human leukocyte antigen; KIR, killer cell immunoglobulin-like receptor; KLR, killer cell lectin-like receptor; LIN, lineage; MPR, major pathologic response; NK, natural killer; NKG2, natural killer group protein 2.