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. 2022 Oct 13;16:3589–3598. doi: 10.2147/DDDT.S382690

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© 2022 Wu et al.

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Exosomes derived from hypoxic glioma cells reduced TMZ sensitivity in glioma cells through carrying miR-106a-5p. Glioma cells were treated with TMZ, TMZ + N-exo, TMZ + H-exo or TMZ + H-exo + miR-106a-5p inhibitor. (A) The viability of glioma cells was assessed by CCK8 assay. (B) The proliferation of glioma cells was detected by EdU staining. (C) The apoptosis of glioma cells was assessed by flow cytometry. **P< 0.01 compared to control. ^##P< 0.01 compared to TMZ. ^{^^}P< 0.01 compared to TMZ + H-exo.