Table 4.

Results of semi-parametric self-controlled case series (SCCS) analyses

Risk window	Incident seizures (n)	Patient-years	Adjusted IRR (95% CI)
1. Primary analysis, antipsychotic medication exposure and risk of incident seizure
Baseline period	88	1049.9	–
14 days pre antipsychotic exposure	9	57.5	1.66 (0.74–3.71)
First 30 days of antipsychotic exposure	26	156.3	1.79 (0.97–3.30)
Subsequent antipsychotic exposure	26	265.6	1.02 (0.53–1.96)
2. Sensitivity analysis, excluding patients died within observation period
Baseline period	87	1043.4	–
14 days pre antipsychotic exposure	8	55.9	1.52 (0.65–3.58)
First 30 days of antipsychotic exposure	26	152.7	1.79 (0.96–3.35)
Subsequent antipsychotic exposure	26	260.6	1.08 (0.56–2.11)
3. Negative outcome control, antipsychotic medication exposure and risk of incident otitis media
Baseline period	261	2691.6	–
14 days pre first antipsychotic exposure	8	119.5	0.74 (0.32–1.73)
First 30 days of antipsychotic exposure	23	306.1	0.77 (0.42–1.39)
Subsequent antipsychotic exposure	42	546.8	0.75 (0.42–1.34)