Table 1.

Univariate and Multivariate analysis of OS and DSS in LUAD

Characteristics		Univariate analysis				Multivariate analysis
		OS		DSS		OS		DSS
		HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Gender	Female	Reference		Reference
	Male	1.070 (0.803-1.426)	0.642	0.989 (0.687-1.424)	0.954
Age	≤65	Reference		Reference
	>65	1.223 (0.916-1.635)	0.172	1.013 (0.701-1.464)	0.944
Smoker	No	Reference		Reference
	Yes	0.894 (0.592-1.348)	0.591	1.040 (0.602-1.796)	0.889
Pathological stage	I&II	Reference		Reference
	III&IV	2.664 (1.960-3.621)	< 0.001	2.436 (1.645-3.605)	< 0.001	2.466 (1.809-3.363)	< 0.001	2.217 (1.490-3.298)	< 0.001
ITGB1	Low	Reference		Reference
	High	1.514 (1.132-2.025)	0.005	1.435 (0.996-2.069)	0.053	1.438 (1.058-1.956)	0.020	1.258 (0.865-1.827)	0.229
ITGB2	Low	Reference		Reference
	High	0.886 (0.665-1.182)	0.412	0.792 (0.549-1.143)	0.213
ITGB3	Low	Reference		Reference
	High	1.089 (0.818-1.451)	0.557	1.088 (0.757-1.563)	0.650
ITGB4	Low	Reference		Reference
	High	1.686 (1.262-2.251)	< 0.001	1.788 (1.238-2.584)	0.002	1.445 (1.047-1.995)	0.025	1.571 (1.075-2.296)	0.020
ITGB5	Low	Reference		Reference
	High	1.311 (0.984-1.747)	0.064	1.190 (0.828-1.711)	0.346	1.024 (0.739-1.419)	0.886
ITGB6	Low	Reference		Reference
	High	0.999 (0.750-1.332)	0.997	0.863 (0.599-1.242)	0.427
ITGB7	Low	Reference		Reference
	High	0.734 (0.548-0.982)	0.037	0.737 (0.510-1.066)	0.105	0.699 (0.519-0.943)	0.019
ITGB8	Low	Reference		Reference
	High	0.965 (0.724-1.285)	0.807	1.074 (0.747-1.545)	0.700

OS: Overall survival, DSS: Disease Specific survival, HR: Hazard Ratio, CI: Confidence interval.