Table 2.

Univariate and Multivariate analysis of OS and DSS in LUSC

Characteristics		Univariate analysis				Multivariate analysis
		OS		DSS		OS		DSS
		HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Gender	Female	Reference		Reference
	Male	1.211 (0.879-1.669)	0.241	1.386 (0.833-2.307)	0.209
Age	≤65	Reference		Reference
	> 65	1.279 (0.960-1.704)	0.093	1.028 (0.668-1.582)	0.899	1.237 (0.921-1.661)	0.158
Smoker	No	Reference		Reference
	Yes	0.585 (0.259-1.325)	0.199	0.393 (0.123-1.251)	0.114
Pathological stage	I&II	Reference		Reference
	III&IV	1.570 (1.139-2.163)	0.006	2.600 (1.648-4.102)	< 0.001	1.601 (1.159-2.212)	0.004	2.626 (1.662-4.150)	< 0.001
ITGB1	Low	Reference		Reference
	High	1.413 (1.076-1.854)	0.013	1.638 (1.068-2.510)	0.024	1.123 (0.814-1.549)	0.481	1.545 (0.931-2.564)	0.092
ITGB2	Low	Reference		Reference
	High	1.051 (0.802-1.378)	0.719	0.998 (0.655-1.521)	0.992
ITGB3	Low	Reference		Reference
	High	1.319 (1.005-1.731)	0.046	1.487 (0.972-2.273)	0.067	1.140 (0.840-1.546)	0.401	1.227 (0.754-1.996)	0.409
ITGB4	Low	Reference		Reference
	High	1.105 (0.843-1.450)	0.470	1.282 (0.840-1.958)	0.250
ITGB5	Low	Reference		Reference
	High	1.358 (1.034-1.785)	0.028	1.294 (0.847-1.975)	0.234	1.242 (0.921-1.674)	0.155
ITGB6	Low	Reference		Reference
	High	1.437 (1.095-1.886)	0.009	1.501 (0.981-2.294)	0.061	1.221 (0.902-1.653)	0.196	1.205 (0.741-1.960)	0.451
ITGB7	Low	Reference		Reference
	High	0.968 (0.737-1.270)	0.814	0.851 (0.557-1.300)	0.454
ITGB8	Low	Reference		Reference
	High	0.993 (0.757-1.301)	0.957	0.641 (0.417-0.984)	0.042			0.594 (0.384-0.918)	0.019

OS: Overall survival, DSS: Disease Specific survival, HR: Hazard Ratio, CI: Confidence interval.