Table 2.

Functional enrichment analysis of high and low risk groups in the TCGA cohort

ONTOLOGY	ID	Description	Gene Ratio	Bg Ratio	p-value	p.adjust	q-value
BP	GO:0006958	complement activation, classical pathway	42/152	137/18670	7.04 e-56	1.64 e-52	1.43 e-52
BP	GO:0002455	humoral immune response mediated by circulating immunoglobulin	42/152	150/18670	5.81 e-54	6.76 e-51	5.90 e-51
BP	GO:0006956	complement activation	42/152	175/18670	8.80 e-51	6.83 e-48	5.96 e-48
BP	GO:0072376	protein activation cascade	42/152	198/18670	2.70 e-48	1.57 e-45	1.37 e-45
BP	GO:0016064	immunoglobulin mediated immune response	43/152	218/18670	5.32 e-48	2.48 e-45	2.16 e-45
CC	GO:0019814	immunoglobulin complex	50/158	159/19717	1.00 e-67	1.57 e-65	1.50 e-65
CC	GO:0042571	immunoglobulin complex, circulating	27/158	72/19717	8.58 e-39	6.73 e-37	6.41 e-37
CC	GO:0072562	blood microparticle	21/158	147/19717	1.48 e-20	7.73 e-19	7.36 e-19
CC	GO:0009897	external side of plasma membrane	29/158	393/19717	7.06 e-20	2.77 e-18	2.64 e-18
CC	GO:0034364	high-density lipoprotein particle	4/158	26/19717	5.17 e-05	0.002	0.002
MF	GO:0003823	antigen binding	42/133	160/17697	1.76 e-54	4.76 e-52	4.20 e-52
MF	GO:0034987	immunoglobulin receptor binding	26/133	76/17697	5.08 e-37	6.86 e-35	6.04 e-35
MF	GO:0008009	chemokine activity	5/133	49/17697	3.25 e-05	0.003	0.003
MF	GO:0042379	chemokine receptor binding	5/133	66/17697	1.38 e-04	0.008	0.007
MF	GO:0015926	glucosidase activity	3/133	14/17697	1.42 e-04	0.008	0.007
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/57	100/8076	4.17 e-07	5.76 e-05	5.19 e-05
KEGG	hsa04060	Cytokine-cytokine receptor interaction	9/57	295/8076	1.97 e-04	0.010	0.009
KEGG	hsa03320	PPAR signaling pathway	5/57	78/8076	2.09 e-04	0.010	0.009
KEGG	hsa05323	Rheumatoid arthritis	5/57	93/8076	4.74 e-04	0.016	0.015
KEGG	hsa04978	Mineral absorption	4/57	59/8076	7.61 e-04	0.021	0.019