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. 2022 Oct 12;13:6005. doi: 10.1038/s41467-022-33434-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Wild-type and mutant myc-tagged coilin NTD constructs expressed in the cytoplasm (NTD, a, b) and nucleus (NTD^NLS, c, d) of HeLa cells. (a, c) Cells were immunostained for NTD-myc and endogenous coilin and Cajal bodies were quantified. Measures of center include the median (horizontal line) and mean (cross). The box is drawn from the 25th to the 75th percentile. The whiskers are drawn from the 5th percentile to the 95th percentiles. a n = 300 control, 93 WT, 277 R8A, 97 R36A, 51 D40A, and 302 D79A cells measured. c n = 300 control, 205 WT, 249 R8A, 48 R36A, 169 D40A, and 299 D79A cells measured. b, d Representative images show myc (magenta), coilin (green), and DAPI (blue). Grayscale bars given in analog-digital units. Scale bars = 10 µm. Images acquired with DeltaVision. Source data are provided as a Source Data file.