Table 2.
List of significantly dysregulated proteins in PPO-KO cells.
| Protein name | Fold change | Gene name | Localization | Protein ID |
|---|---|---|---|---|
| 5-Aminolevulinate synthase 1 | 77.77 | ALAS1 | Mitochondrial matrix, cytosol, nucleus | P13196 |
| Coiled-coil domain containing 32 | 6.08 | CCDC32 | Nucleus | Q9BV29 |
| Gametocyte-specific factor 1 | 3.39 | GTSF1 | Cytosol | Q8WW33 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | 2.22 | CACNA2D1 | Plasma membrane | P54289 |
| Methylated-DNA–protein-cysteine methyltransferase | 2.05 | MGMT | Nucleus, membrane, cytosol, mitochondria | P16455 |
| TBC1 domain family member 2A | 2.01 | TBC1D2 | Cytosol, nucleoplasm, plasma membrane | Q9BYX2 |
| Beta-enolase | 1.85 | ENO3 | Cytosol, membrane | P13929 |
| Cytochrome b-c1 complex subunit 6, mitochondrial | 0.63 | UQCRH | Mitochondria, OXPHOS complex III | P07919 |
| Cytochrome c oxidase subunit 6C | 0.57 | COX6C | Mitochondria, OXPHOS complex IV | P09669 |
| Cytochrome c1, heme protein, mitochondrial | 0.55 | CYC1 | Mitochondria, OXPHOS complex III | P08574 |
| Cytochrome c oxidase subunit NDUFA4 | 0.52 | NDUFA4 | Mitochondria, OXPHOS complex IV | O00483 |
| Nurim | 0.51 | NRM | Nuclear membrane | Q8IXM6 |
| Cytochrome c oxidase subunit 6B1 | 0.50 | COX6B1 | Mitochondria, OXPHOS complex IV | P14854 |
| Lanosterol 14-alpha demethylase | 0.49 | CYP51A1 | Endoplasmic reticulum, membrane | Q16850 |
| Cytochrome c oxidase subunit 3 | 0.46 | MT-CO3 | Mitochondria, OXPHOS complex IV | P00414 |
| DBH-like monooxygenase protein 1 | 0.45 | MOXD1 | Cytosol, membrane, secretory granule | MOXD1 |
| Cytochrome c oxidase subunit 6A1, mitochondrial | 0.39 | COX6A1 | Mitochondria, OXPHOS complex IV | P12074 |
| ADP-ribosylation factor-like protein 6-interacting protein 6 | 0.38 | ARL6IP6 | Membrane | Q8N6S5 |
| Cell division cycle protein 20 homolog | 0.35 | CDC20 | Nucleus, cytosol | Q12834 |
| Cytochrome c | 0.34 | CYCS | Mitochondria, cytosol | P99999 |
| Cytochrome B561 family member D2 | 0.26 | CYB561D2 | Endoplasmic reticulum, membrane | O14569 |
| Protoporphyrinogen oxidase | NaN | PPOX | Mitochondrial matrix | P50336 |
Value represents the fold change of the protein expression level relative to the control group. Heme-related proteins are shown in bold.
NaN not a number.