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. 2022 Oct 12;7:117. doi: 10.1038/s41541-022-00544-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Endpoint titers of the generated antibodies were evaluated in the sera of individual animals after three immunizations. Horizontal lines indicate the median titer and the x-axis grouping indicates the target-specificities of the generated responses. Titers of generated antibodies specific to MultiTEP are significantly lower than titers of antibodies specific to Tau2-18 (*p = 0.0173, Ordinary One-way Anova) (b) AV-1980R/A induced IgG isotypes of antibodies. Isotypes were analyzed in sera of individual animals diluted 1:2000 after the third immunization. c Dynamics of humoral immune responses in individual animals (n = 6 at the start, #CH2C was euthanized on week 12, and #CH2D was euthanized on week 24) immunized with AV-1980R/A on weeks 0, 2, 6, 26, and 46.