Table 6.

Sensitivity analysis - risk and cumulative incidence of symptom-based CCS categories

CCS Category and Time Period	Mutually Exclusivea	Case Cumulative Incidence	Control Cumulative Incidence	Risk Ratio [95% CI]
Abdominal pain
Late	Yes	1.8%	1.7%	1.05 [0.95,1.17]
Late	No	5.4%	5.3%	1.01 [0.95,1.07]
Pre-existing conditions	Yes	0.2%	0.2%	0.87 [0.63,1.20]
Pre-existing conditions	No	0.8%	1.1%	0.73 [0.63,0.85] *
Anosmia
Late	Yes	0.3%	0.1%	3.88 [2.79,5.40] *
Late	No	0.3%	0.1%	3.21 [2.37,4.35] *
Pre-existing conditions	Yes	0.0%	0.0%	0.50 [0.11,2.28]
Pre-existing conditions	No	0.0%	0.0%	0.33 [0.08,1.46]
Conditions associated with dizziness or vertigo
Late	Yes	1.7%	1.6%	1.05 [0.94,1.16]
Late	No	5.5%	5.3%	1.04 [0.98,1.11]
Pre-existing conditions	Yes	0.2%	0.2%	1.08 [0.82,1.44]
Pre-existing conditions	No	1.1%	1.1%	1.02 [0.89,1.16]
Malaise and fatigue
Late	Yes	1.4%	0.9%	1.60 [1.41,1.81] *
Late	No	2.7%	1.9%	1.46 [1.33,1.60] *
Pre-existing conditions	Yes	0.3%	0.1%	2.89 [2.10,3.98] *
Pre-existing conditions	No	0.6%	0.3%	2.07 [1.69,2.54] *
Nausea and vomiting
Late	Yes	0.7%	0.7%	0.95 [0.80,1.12]
Late	No	1.4%	1.5%	0.90 [0.80,1.01]
Pre-existing conditions	Yes	0.1%	0.1%	0.81 [0.49,1.32]
Pre-existing conditions	No	0.2%	0.3%	0.61 [0.45,0.82] *
Nonspecific chest pain
Late	Yes	1.7%	1.2%	1.39 [1.24,1.55] *
Late	No	3.9%	2.8%	1.38 [1.28,1.49] *
Pre-existing conditions	Yes	0.4%	0.2%	2.39 [1.85,3.10] *
Pre-existing conditions	No	0.9%	0.5%	1.84 [1.56,2.16] *

^aMutually exclusive Yes represents our original analysis where pre-existing conditions were removed from calculating acute and persistent and late counts. Mutually exclusive No represents the sensitivity analysis where we allowed pre-existing conditions to be counted in the acute and persistent and late time periods. * Represents risk ratios with p < 0.05