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. 2022 Oct 10;8(2):e002639. doi: 10.1136/rmdopen-2022-002639

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Serum neutralising activity against Wu01, Omicron BA.1 and Omicron BA.2 4 and 12 weeks after mRNA booster vaccination in patients with and without MTX pause and non-immunosuppressed persons. The p values shown are based on the Mann-Whitney U test, which was used to analyse the differences between the groups. Fifty percent inhibitory serum dilutions (ID₅₀s) were determined by pseudovirus neutralisation assays. Dot plots and numbers above the graph illustrate the geometric mean ID₅₀ and error bars indicate the 95% CIs. Dotted black lines display the lower limit of quantification of the neutralisation assay (ID₅₀ of 10). ID₅₀s below the LLOQ (ID₅₀=10) were assigned to half the LLOQ (ID₅₀=5). LLOQ, lower limit of quantification; MTX, methotrexate; NIP, non-immunosuppressed persons.