Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 22;47(12):2071–2080. doi: 10.1038/s41386-022-01413-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A Schematic of Mergeomics pipeline. MDF marker dependency filtering, MSEA marker set enrichment analysis, KDA key driver analysis. B Overlap (%) between CUD-associated modules and THC-correlated modules (C) or between CUD-associated modules and both THC-correlated and interconnected modules (D). The overlap (%) is calculated as the number of overlapping modules divided by the total number of CUD-associated modules. D Visualization of Bayesian network shared by CUD-associated modules in female and male NAc. Key driver genes are represented by large size diamond nodes. Orange, blue, and grey nodes denote genes (male NAc orange module, genes in female NAc blue module, and genes in the BN but not in the two aforementioned modules, respectively. CUD-associated genes identified by Mergeomics using loci with p < 0.001 from the Johnson et al. [11] CUD GWAS are labeled with red borderline. The bar plot depicts pathway enrichment of the genes in the CUD subnetwork. BN, Bayesian network.