FIGURE 1.

The CRyPTIC Consortium has collected 20 637 clinical tuberculosis (TB) samples worldwide. a, b) Layout and concentrations of the anti-TB drugs on the a) UKMYC5 and b) UKMYC6 microdilution 96-well plates. All concentrations are in mg·L⁻¹; for clarity only the first and last concentrations in each doubling series are given. The two unlabelled wells in the bottom right-hand corner contain no antibiotic and are therefore positive controls. Note that all doubling dilution series are based around 1 mg·L⁻¹ with the exception of INH which is based around 0.1 mg·L⁻¹. c) Geographical distribution of CRyPTIC laboratories and samples collected. 14 laboratories from 11 countries collected data from 27 countries. Each country is coloured depending on the number of originating samples using a logarithmic scale. PAS: para-aminosalicylic acid.