TABLE 2.
99th percentiles of the wild-type population as determined by three different algorithmic approaches and the resulting proposed epidemiological cut-off values (ECOFF/ECVs) for the 13 drugs on the UKMYC6/5 plates
| ECOFFinder | Direct measurement on gWT (mg · L −1 ) | Interval regression on gWT (mg · L −1 ) (both) | Proposed ECOFF/ECV (mg · L −1 ) | |||
| UKMYC6 | UKMYC5 | UKMYC6 | UKMYC5 | |||
| Isoniazid | 0.06 | 1.6 | 0.1 | 0.25 | 0.1 | |
| Rifampicin | 0.08 | 0.5 | 0.25 | 0.52 | 0.5 | |
| Ethambutol | 2.1 | 4.0 | 4 | 4 | 3.7 | 4 |
| Moxifloxacin | 0.74 | 0.75 | 1 | 2 | 1.4 | 1 |
| Levofloxacin | 0.63 | 0.72 | 1 | 4 | 1.3 | 1 |
| Kanamycin | 3.1 | 2.9 | 8 | 4 | 7.0 | 4 |
| Amikacin | 0.34 | 0.31 | 1 | 1 | 1.6 | 1 |
| Ethionamide | 3.1 | 3.0 | 4 | 4 | 4.0 | 4 |
| Rifabutin | 0.12 | 0.12 | 0.09 | 0.12 | ||
| Clofazimine | 0.12 | 0.078 | 0.25 | 0.5 | 0.34 | 0.25 |
| Linezolid | 0.81 | 0.95 | 1 | 1 | 1.6 | 1 |
| Delamanid | 0.010 | 0.019 | 0.12 | 0.12 | 0.11 | 0.12 |
| Bedaquiline | 0.11 | 0.11 | 0.25 | 0.25 | 0.20 | 0.25 |
gWT: genotypically wild-type.