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IC50 values of compound 8 against PI3Kα and VEGFR-2.
| Compound | PI3Kα enzymatic IC50 (nM)* | VEGFR-2enzymatic IC50 (nM)* |
|---|---|---|
| 8 | 2.21 ± 0.11 | 86 ± 4 |
| LY294002 | 6.18 ± 0.2 | N/A |
| Sorafenib | N/A | 34 ± 0.86 |
N/A not applied.
*Mean activity values of triplicate results.
