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. 2022 Sep 29;16:895481. doi: 10.3389/fncir.2022.895481

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Copyright © 2022 Waterhouse, Predale, Plummer, Jensen and Chandler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of axon collaterals from LC neurons projecting to mPFC. The bar graph (n = 4 mice) indicates percentage of LC-NE axons at each brain region that originate from EGFP + mPFC-projecting LC-NE neurons. LC-NE neurons are represented as percent of total LC-NE inputs (sum of EGFP + and tdTomato +) in select brain regions. mPFC, medial prefrontal cortex; A24, ventral anterior cingulate; insular ctx, insular cortex; M1, primary motor cortex; piriform ctx, piriform cortex; BNST, bed nucleus of the stria terminalis; CA1, area CA1 of the hippocampus; BLA, basolateral amygdala; BMA, basomedial amygdala; LH, lateral hypothalamus; PVN, paraventricular hypothalamic nuc; AV, anteroventral thalamic nuc; PV, paraventricular thalamic nuc; VL, ventrolateral thalamic nuc; VM, ventromedial thalamic nuc; MG, medial geniculate nuc; Sup. coll., superior colliculus; SNr, substantia nigra. Adapted from Plummer et al. (2020).