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. 2022 Sep 29;13:1018639. doi: 10.3389/fendo.2022.1018639

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Copyright © 2022 Zhao, Yang, Ji, Su, Fan, Wang and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG and GO enrichment analysis of DEGs. (A) Z-score results for the top 12 GO terms, including the top 4 BPs, CCs, and MFs. (B) Enrichment results for DEGs and the top 15 GO terms. (C, D) Relationships between DEGs and the top enriched KEGG pathways by different methods. Z-scores were defined as follows:(upregulated genes–downregulated genes)/total genes.DEGs: differentially expressed genes; GO: Gene Ontology; BP: biological process; CC: cellular component; MF: molecular function. KEGG: Kyoto Encyclopedia of Genes and Genomes.