TABLE 5.

Coefficient estimates from generalized linear mixed models that tested differences in fractal analysis metrics between genotype × KI67 combinations.

Comparison	Density		Fractal dimension		Circularity		Lacunarity		Span ratio
	Estimate	P-value	Estimate	P-value	Estimate	P-value	Estimate	P-value	Estimate	P-value
KO KI67– vs. KO KI67+	0.06	0.49	0.05	< 0.01	–0.02	0.99	0.16	< 0.01	–0.01	0.99
KO KI67– vs. WT KI67–	0.03	0.86	0.02	0.48	0.03	0.97	–0.01	0.99	0.02	0.94
KO KI67+ vs. WT KI67+	–0.03	0.92	0.004	0.99	0.13	0.40	0.01	0.99	–0.08	0.42
WT KI67– vs. WT KI67+	–0.01	0.99	0.03	0.05	0.09	0.62	0.17	< 0.01	–0.11	0.03

Statistically significant results are in bold text.