Table 2.

Time to event comparison between the combined reduced and full dose DOACs.

Events (%/yr)	Reduced dose DOACs combined group rate per person-yeara (n = 514)	Full dose DOACs combined group rate per person-yeara (n = 199)	p-value univariable (from log rank test with Kaplan-Meier curve)	Proportional hazards multivariable hazard ratio: Low dose as reference (95 % CI)*	p-value from proportional hazards multivariable model*
SSE	1.02	0	0.035	N/A b	N/A b
CNS bleeding	1.45	0.44	0.109	0.291 (0.054 to 1.56)	0.204
Non-CNS bleeding	10.89	4.15	< 0.001	0.72 (0.395 to 1.312)	0.249
All-cause mortality	6.24	1.75	< 0.001	0.338 (0.142 to 0.807)	0.013

SSE = Stroke and systemic embolization; CNS = central nervous system.

^aRates per person-year may be interpreted as annual percentages.

^bToo few cases in one group for multivariable model.

^*p values and hazard ratio adjusted for multivariable baseline differences.