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. 2022 Sep 29;12:1006477. doi: 10.3389/fonc.2022.1006477

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Copyright © 2022 Wu, Chen, Gu, Li, Yue, Lyu, Cui, Zhang, Liu, Zhu, Liao, Zhang, Sun and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor-infiltrating B cells are positively associated with patient survival in lung cancer. (A) TCGA LUNG data showing positive correlation between B cell frequency in lung tumor and overall survival (OS), disease specific survival (DSS), disease free interval (DFI), and progression free interval (PFI). B cell set comprises five specific B cell markers (CD19, CD79A, CD79B, BLK, and CD20). (B) TIMER data showing association between B cell infiltrates and clinical outcome in human cancers. Z-score > 0: increased risk, Z-score < 0: decreased risk. (C) Kaplan-Meier curves displaying positive association of B cell infiltrates with patient survival in lung adenocarcinoma (LUAD) by TIMER, XCELL, and MCP-counter algorithms. The infiltration level is equally divided into low and high levels. The hazard ratio (HR) and the log-rank p value for Kaplan-Meier curve were shown in plots (A, C).