Figure 5.

B cell deprivation dampens tumor infiltration of immune cells in lung cancer. (A) FACS data showing reduced abundance of immune cells in tumor from mice with αCD20-mediated B cell depletion (n = 3). (B, C) FACS data showing decreased tumor-infiltrating lymphocytes (B) and myeloid cells (C) by αCD20-mediated B cell depletion (n = 3). (D, E) FACS data showing differential changes of lymphocytes (D) and myeloid cells (E) in lung tissue by αCD20-mediated B cell depletion (n = 5). (F) FACS data showing augmented Treg cell frequency in both lung tumor (n = 3) and lung tissue (n = 5) by αCD20-mediated B cell depletion. Student’s t test (two tailed, unpaired) was performed. Data represented means ± SEM. *p < 0.05; **p < 0.01; ns, not statistically significant.