Figure 7.

B cell subsets are diminished by CD20 blockade in lung cancer. (A) FACS data showing fewer memory B cells in multiple tissues and organs from mice with αCD20-mediated B cell depletion. (B) FACS data showing reduced plasma cells in TDLN and tumor, but not lung tissue and spleen from mice with αCD20-mediated B cell depletion. (C) FACS data showing decreased Breg cells in multiple tissues and organs from mice with αCD20-mediated B cell depletion. TDLN: mediastinum lymph node. Lung tissue: n = 5; TDLN: n = 5; Spleen: n = 5; Lung tumor: n = 3. Student’s t test (two tailed, unpaired) was performed. Data represented means ± SEM. *p < 0.05; **p < 0.01; ns, not statistically significant.