Table 1.

Expression profiles of miR-1258 in human cancers.

Systems	RNAs	Cancer type	Role	Expression	Sources	Sample number	Biological functions	Targets	Upstream gene	References
Digestive system	miR-1258	HCC	tumor suppressor	downregulation	tissues and cell lines	38 paired	Inhibit cell proliferation, migration, invasion and glycolysis process	RPN2	Circ_0046599	[21]
	miR-1258			downregulation	tissues and cell lines	37 paired	Inhibit cell proliferation, cell cycle transition, migration, invasion, EMT and facilitate cell apoptosis	SERBP1	Circ_0046600	[22]
	miR-1258			/	/	/	Inhibit cell migration and invasion	TCF4	Kindlin-2	[23]
	miR-1258			downregulation	tissues and cell lines	20 paired	Inhibit cell proliferation, cell cycle transition, migration, stemness, facilitate cell apoptosis and increase chemosensitivity	CKS1B	/	[24]
	miR-1258			downregulation	tissues and cell lines	20 paired	Inhibit cell migration and invasion	Smad2/3	LINC01278	[25]
	miR-1258	GC	tumor suppressor	downregulation	tissues and cell lines	116 paired	Inhibit cell invasion and metastasis	HPSE		[26]
	miR-1258	CRC	tumor suppressor	downregulation	cell lines	/	Inhibit cell proliferation and migration	RPN2	circ_SMAD2	[27]
	miR-1258			downregulation	tissues and cell lines	60 paired	Inhibit cell proliferation and arrest cell cycle transition	E2F8	/	[28]
	miR-1258			/	/	/	Inhibit cell proliferation and migration	CKS1B	/	[29]
	miR-1258	OSCC	tumor suppressor	downregulation	tissues	89 paired	Inhibit cell proliferation and invasion	SP1	c‐Myb	[30]
	miR-1258	EC	tumor suppressor	downregulation	tissues	40 paired	Inhibit cell proliferation, migration and invasion	/	LncRNA ASB16-AS1	[31]
Respiratory system	miR-1258	NSCLC	tumor suppressor	downregulation	tissues and cell lines	50 paired	Inhibit cell proliferation, cell cycle transition and induce cell senescence and apoptosis	GRB2	/	[32]
	miR-1258		tumor suppressor	downregulation	tissues	53 paired	Inhibit cell invasion	/	/	[33]
	miR-1258		tumor suppressor	downregulation	serum and cell lines	96	Inhibit cell proliferation, migration and invasion	RHOV	circ_0000519	[34]
Genitourinary system	miR-1258	BC	tumor suppressor	downregulation	tissues	83 paired	Inhibit cell proliferation, migration and stemness	KDM7A	circ_002178	[35]
	miR-1258		biomarker	downregulation	tissues	1166	prognostic biomarker	/	/	[36]
	miR-1258		tumor suppressor	downregulation	cell lines	/	Inhibit cell proliferation, cell cycle transition and induce cell apoptosis	E2F1	/	[37]
	miR-1258		biomarker	downregulation	tissues	239	prognostic biomarker	/	/	[38]
	miR-1258		tumor suppressor	downregulation	tissues and cell lines	13 paired	Inhibit cell invasion and experimental brain metastasis	HPSE		[40]
	miR-1258	CC	tumor suppressor	downregulation	cell lines	/	Inhibit cell proliferation, invasion, migration and promote cell apoptosis	E2F1	/	[41]
Other	miR-1258	Myeloma	tumor suppressor	downregulation	tissues	113	Inhibit cell proliferation and promote cell apoptosis	PD-L1	/	[42]
	miR-1258	Thyroid carcinoma	tumor suppressor	downregulation	cell lines	/	Inhibit the cell viability, migration and invasion	TMPRSS4	/	[43]
	miR-1258	Glioblastoma	tumor suppressor	downregulation	tissues	38	Inhibit cell proliferation, migration, invasion and increase chemosensitivity	E2F1	/	[44]
	miR-1258	Osteosarcoma	tumor suppressor	downregulation	tissues and cell lines	60 paired	Inhibit cell proliferation and cell cycle transition	AKT3	/	[45]

HCC, hepatocellular carcinoma; OSCC, oral squamous cell carcinoma; CRC, colorectal cancer; EC, esophageal cancer; NSCLC, non-small cell lung cancer; BC, breast cancer; CC, cervical cancer; GC, gastric cancer.