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. 2022 Sep 29;16:988096. doi: 10.3389/fnins.2022.988096

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Copyright © 2022 Rêgo, Silva, Mello and Leslie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) No differences in the distance traveled were observed among the groups. (B) Females traveled a longer distance than males (p = 0.01). (C) No significant effect was observed for the duration in the inner zone among groups (p = 0.11). (D) The males spent more time than females in the central area (p = 0.01). (E) No significant differences in the duration (sec) in the inner and outer zones were observed. (F) CFA + F group spent less time in the open arms in the EPM when compared to Naïve (p = 0.03) and Sham 1 (p = 0.005). (G) CFA + F spent more time in the closed arms in the EPM when compared to Naïve (p = 0.028) and Sham 1 (p = 0.005). OF, open field; EPM, elevated plus maze (*p < 0.05; **p < 0.01; ***p < 0.001).