Table 1.
The main PK parameters of tilmicosin in lung tissues of the M. gallisepticum infected chickens.
| Parameter | Units | 1 mg/kg | 30 mg/kg |
|---|---|---|---|
| t1/2kel | h | 48.46 | 50.60 |
| Tmax | h | 12.00 | 12.00 |
| Cmax | μg/g | 0.12 | 6.19 |
| AUC | μg·h/g | 13.62 | 464.23 |
| MRT | h | 53.60 | 50.88 |
| CL/F | l/h/kg | 0.09 | 0.06 |
t1/2kel, elimination half-life; tmax, the time of peak concentration; Cmax, the maximum concentration of drug in samples; AUC, the area under the concentration–time curve; MRT, mean residence time; CL/F, clearance divided by bioavailability.