Table 3.
The PK/PD parameters of tilmicosin against M. gallisepticum in vivo using the Emax model employed by WinNonlin software.
| Parameter | Value |
|---|---|
| Emax | 4.78 |
| EC50 | 7,174.57 |
| E0 | 0.64 |
| N | 0.79 |
| R2 | 0.92 |
Emax, the reduction in log CFU/lung for the untreated control chicken. E0, the maximum reduction after administration that represents the maximum antibacterial effect. EC50, the AUC/MIC value required to achieve 50% of the maximal antibacterial effect. N, the Hill coefficient which describes the steepness of the AUC/MIC and effect curve.