TABLE 1.

List of matrix metalloproteinases (MMPs), their enzymatic names, major substrates, and cellular location.

MMP name	Enzymatic names	Role in stages of cancer development/Major substrates	Cellular location
MMP-1	Collagenase 1 or interstitial collagenase	Invasion/native collagens (types II > I > II, VII, VIII, X, and XI) and denatured collagens	Macrophages, lymphocytes, and vascular endothelial cells (Mach et al., 1999)
MMP-2	Gelatinase A	Angiogenesis, invasion, inflammation/native collagens (types I, II, III, IV, V, VII, X, and XI), gelatin, elastin, and fibronectin	Macrophages, lymphocytes, and endothelial cells (Oviedo-Orta et al., 2008)
MMP-3	Stromelysin-1	Inflammation/nontriple helical regions of native collagens (types III, IV, V, VII, IX, X, and XI) and gelatin	Macrophages, T-lymphocytes, and endothelial cells (Choi et al., 2019)
MMP-7	Matrilysin-1	Inflammation/nonhelical segments of native collagens (types IV, V, IX, X, and XI), gelatin, elastin, and fibronectin	Endothelial cells and macrophages (Holnthoner et al., 2006)
MMP-8	Collagenase 2 or neutrophil collagenase	Native collagens (types I > II > III, VII, and X), gelatin, fibronectin, laminin subunit gamma-2, entactin, aggrecan, tenascin, Brevican core protein precursor, myelin basic protein, and fibrinogen	Vascular smooth muscle cells, macrophages, T-cells, and vascular endothelial cells (Yang et al., 2020)
MMP-9	Gelatinase B	Inflammation, metastasis/native collagens (types I, IV, V, XI, and XIV), gelatin, elastin, vitronectin, and laminin	Macrophages, T-lymphocytes, neutrophils, and endothelial cells (Ardi et al., 2007)
MMP-10	Stromelysin-2	Inflammation/collagens (Types I, III, IV, and V), gelatin	Endothelial cells and macrophages (Orbe et al., 2009)
MMP-11	Stromelysin-3	Gelatin, fibronectin, and collagen Type IV	Smooth muscle cells, macrophages, fibroblasts and B-cells, and endothelial cells (Chen et al., 2013)
MMP-12	Macrophage metalloelastase	--------------------	Macrophage (Carmeliet et al., 1997)
MMP-13	Collagenases 3	Inflammation/native collagens (Types II > III > I, VI, VII, IX, X, and XIV), gelatin, fibronectin, laminin subunit Gamma-2	Fibroblasts and macrophages, Lymphocytes and macrophages Neutrophils (Mescher, 2017)
MMP-14	Membrane-anchored MT1-MMP	Angiogenesis/native collagens (Types I, II, and III), Gelatin, Fibronectin	Vasculardothelial cells, macrophages, and fibroblasts (Zigrino et al., 2016)
MMP-15	MT 2-MMP	Fibronectin, tenascin, entactin	Fibroblasts, leukocytes, and T lymphocytes (Edsparr et al., 2011)
MMP-16	MT3 –MMP	Collagen type III, gelatin	Leukocytes and T-lymphocytes (Bar-Or et al., 2003)
MMP-17	MT4- MMP	Gelatin, fibrin, fibrinogen, myelin basic protein	Monocytes and B-cells and fibroblast (Bar-Or et al., 2003)
MMP-19	Stromelysin-4	Native collagen type IV, gelatin	Fibroblasts T lymphocytes monocytes (Hieta et al., 2003)
MMP-21	X-MMP—(Xenopus)	Gelatin, aggrecan	Fibroblasts and macrophages (Skoog et al., 2006)
MMP-23	Cysteine Array MMP (CA-MMP) or femalysin	Gelatin, casein, fibronectin	T cells (Moogk et al., 2014)
MMP-24	MT5 –MMP	Fibronectin, gelatin, chondroitin sulphate proteoglycan	T-lymphocytes and leukocytes (Bar-Or et al., 2003)
MMP-25	MT6-MMP or leukolysin	Native collagen type IV, celatin	Monocytes and leukocytes (Pei, 1999)
MMP-26	Matrilysin-2	Native collagen type IV, gelatin, fibronectin, vitronectin, fibrinogen	Endothelial cells, fibroblasts, and macrophages (Skoog et al., 2006)