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. 2022 Sep 27;24(5):412. doi: 10.3892/ol.2022.13532

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — KM-Plotter (http://www.kmplot.com) was used to examine the effect of SPARC mRNA expression on prognosis of patients with NSCLC. (A) SPARC mRNA expression was positively associated with overall survival in patients with NSCLC. (B) Relationship between SPARC mRNA expression and overall survival in lung adenocarcinoma. (C) Relationship between SPARC mRNA expression and overall survival in AJCC N1. (D) Relationship between SPARC mRNA expression and overall survival in females. (E) Relationship between SPARC mRNA expression and overall survival in males. (F) Relationship between SPARC mRNA expression and overall survival when surgical margins are negative. (G) Relationship between SPARC mRNA expression and overall survival for patients who never smoked. (H) Relationship between SPARC mRNA expression and overall survival after excluding those who never smoked. (I) SPARC mRNA expression was positively associated with post-progression survival in patients with NSCLC. (J) Relationship between SPARC mRNA expression and post-progression survival in females. (K) Relationship between SPARC mRNA expression and post-progression survival when surgical margins were negative. (L) SPARC mRNA expression was positively associated with first progression survival in patients with NSCLC. (M) Relationship between SPARC mRNA expression and first progression survival in lung adenocarcinoma. (N) Relationship between SPARC mRNA expression and first progression survival in AJCC stage N1. (O) Relationship between SPARC mRNA expression and first progression survival in females. (P) Relationship between SPARC mRNA expression and first progression survival in males. (Q) Relationship between SPARC mRNA expression and first progression survival when surgical margins were negative. (R) Relationship between SPARC mRNA expression and first progression survival after excluding those who never smoked. Effects of SPARC mRNA expression on patients with NSCLC according to the Oncomine database (www.oncomine.org). The datasets within the Oncomine database were used for bioinformatics analysis to examine the expression of SPARC mRNA during the development of NSCLC. SPARC expression in NSCLC tissues was higher than that in normal lung tissues. Values in the box plots are expressed as the median (interquartile range). (S) SPARC mRNA expression in Lung tissue vs Squamous cell lung Carcinoma. (T) SPARC mRNA expression in lung tissue vs. lung adenocarcinoma. (U) SPARC mRNA expression in lung tissue vs. squamous cell lung carcinoma. SPARC, secreted protein acidic and cysteine rich; NSCLC, non-small cell lung cancer; HR, hazard ratio; AJCC, American Joint Committee on Cancer; KM, Kaplan-Meier.