(A-D) Analysis in the UALCAN database. (A) Expression of SPARC gene in different samples of LUAD. (B) Relationship between SPARC mRNA expression level and survival level of patients with LUAD. (C) Expression of SPARC gene in different LUSC specimens. Values in the box plots are expressed as the median (interquartile range). (D) Relationship between SPARC mRNA expression level and survival of patients with LUSC. (E-J) Analysis in the Human Protein Atlas database. H&E staining of (E) normal lung tissue, (F) LUAD and (G) LUSC. Immunohistochemical staining for SPARC in (H) normal lung tissue, (I) LUAD and (J) LUSC (scale bars, 200 µm). SPARC was positive in LUAD and LUSC. SPARC, secreted protein acidic and cysteine rich; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma.