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. 2022 Sep 29;12:971697. doi: 10.3389/fonc.2022.971697

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Copyright © 2022 Faure Conter, Calaminus, Nicholson, Idbaih, Hoang Xuan, Vasiljevic, Morana, Szathmari, Ajithkumar and Frappaz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) CNS Germinoma is composed of large round neoplastic cells, with clear cytoplasm, and high nuclear-to-cytoplasmic ratio. They are embedded in an inflammatory stroma of lymphocytes (mostly T cells) and histiocytes (A, Haematoxylin, Phloxine, Saffron (HPS) staining, original magnification (OM) x 200). Neoplastic cells demonstrate membranous and golgian expression of CD117/c-Kit (B, OM x 200). Nuclei are immunopositive for OCT4 (Octamer-binding transcription factor 4) (C, OM x 200). (D) CNS immature teratoma is characterized by a variable admixture of fetal and/or embryonic tissues derived from the three germ layers: ectoderm, mesoderm, and endoderm. Rosette-like structures resembling primitive neural tube are typical of immature neuroectodermal components (D, HPS staining, OM x 50).