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. 2022 Sep 29;16:964691. doi: 10.3389/fncel.2022.964691

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Copyright © 2022 Thouta, Waldbrook, Lin, Mahadevan, Mezeyova, Soriano, Versi, Goodchild and Parrish.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of low concentration of TTX on intrinsic excitability of pyramidal neurons using a current ramp injection. (A) Representative voltage traces of pyramidal neurons recorded in response to a current injection ramp (4 s ramp from 0 pA to 480 pA; 120 pA/s) without (black) and with (red) application of 3 nM TTX. (B) Scatter plot showing significant impact on the number of APs with application of 3 nM TTX. (C–E) Using this protocol, we found that the rheobase (C), AP amplitude (D) and spike latency (E) was also significantly altered with application of 3 nM TTX (paired 2 tailed t-test, *p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001, n = 13 neurons).