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. 2022 Sep 29;16:964691. doi: 10.3389/fncel.2022.964691

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Copyright © 2022 Thouta, Waldbrook, Lin, Mahadevan, Mezeyova, Soriano, Versi, Goodchild and Parrish.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TTX and phenytoin (PHY) reduces seizure-like events in a clear concentration dependent manner. Seizure-like events are reduced in a TTX (A) and PHY (B) concentration-dependent manner (one-way ANOVA with a Dunnett’s test, *p < 0.05, ***p < 0.001, ****p < 0.0001, n = 6 for TTX n = 5–7 for PHY).