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. 2022 Oct 4;2022:9294148. doi: 10.1155/2022/9294148

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Copyright © 2022 Hong Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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miR-335-5p downregulation alleviates fibrosis and apoptosis in the right ventricle. (a) Representative images of HE, Masson, and TUNNEL in the RV of hypoxia/su5416 mice; scale bars indicate 25 μm. (b) Histological examination indicated that miR-335-5p inhibition reduced cardiomyocyte cross-sectional areas. (c) Decreased ANP and β-MHC in the RV of mice treated with antagomiR-335-5p as determined by RT-qPCR. (e) Masson staining indicated that miR-335-5p inhibition reduced fibrosis. (f) Quantified data showing the apoptotic rate after being treated with antagomiR-335-5p; Data are presented as mean ± SD; n = 6 per group; ^∗P < 0.05 and ^∗∗P < 0.01 versus the control group; ^#P < 0.05 and ^##P < 0.01 versus the antagomir NC group.